個(gè)人概況
姓名：李亞楠
職稱：講師
學(xué)位：理學(xué)博士
專業(yè)：生物化學(xué)與分子生物學(xué)
辦公室：敏思樓322
聯(lián)系方式：yananli1997@163.com
教育經(jīng)歷
2015.09–2019.07 信陽師范大學(xué) 學(xué)士
2019.09–2025.01 上海科技大學(xué) 博士
工作經(jīng)歷
2025.01-至今 信陽師范大學(xué) 講師
研究領(lǐng)域
1. 單分子技術(shù)解析核酸代謝的分子機(jī)制
2. 核酸代謝在褐飛虱與水稻互作中的功能機(jī)制
獲獎(jiǎng)及榮譽(yù)
1．第一屆全國大學(xué)生生命科學(xué)競賽一等獎(jiǎng)
2．第四屆全國現(xiàn)代生物物理方法與技術(shù)暨2023東亞單分子生物學(xué)學(xué)術(shù)研討會(huì)優(yōu)秀墻報(bào)獎(jiǎng)
3．上海市優(yōu)秀畢業(yè)生
論文發(fā)表
第一作者&通訊（含共同）
1. Jing, S.#*, Xu, J.#, Zheng, F., Jin, J., Huang, X., Mao, L., Wang, F., Zhang, H., Xu, J., Yang, J., Chen, R., Yu, B., Liu, Q.*, and Li, Y.* (2025) NlAgo3 and NlBiwi are essential for piRNAs biogenesis and female reproduction in Nilaparvata lugens. Insect Biochem Mol Biol, 182, 104346.
2. Li, Y.#, Liu, C.#, Jia, X., Bi, L., Ren, Z., Zhao, Y., Zhang, X., Guo, L., Bao, Y., Liu, C., Li, W.* and Sun, B.* (2024) RPA transforms RNase H1 to a bidirectional exoribonuclease for processive RNA-DNA hybrid cleavage. Nat Commun, 15, 7464.
3. Jia, X.#, Li, Y.#, Wang, T., Bi, L., Guo, L., Chen, Z., Zhang, X., Ye, S., Chen, J., Yang, B. and Sun, B.* (2023) Discrete RNA-DNA hybrid cleavage by the EXD2 exonuclease pinpoints two rate-limiting steps. EMBO J, 42, e111703.
4. Liu, C.#, Wang, L.#, Li, Y.#, Guo, M., Hu, J., Wang, T., Li, M., Yang, Z., Lin, R., Xu, W., Chen, Y.H., Luo, M.C., Gao, F., Chen, J.Y., Sun, Q.W., Liu, H.B., Sun, B.*, and Li, W.* (2023) RNase H1 facilitates recombinase recruitment by degrading DNA-RNA hybrids during meiosis. Nucleic acids res, 51, 7357-7375.
參與作者
1. Li, X., Bi, L., Zhang, S., Xu, Q., Xia, W., Tao, Y., Wu, S., Li, Y., Le, W., Kang, W. et al. (2025) Single-Molecule Insight Into alpha-Synuclein Fibril Structure and Mechanics Modulated by Chemical Compounds. Adv Sci (Weinh), e2416721.
2. Song, X., Chen, Z., Sun, W., Yang, H., Guo, L., Zhao, Y., Li, Y., Ren, Z., Shi, J., Liu, C. et al. (2024) CRISPR-AsCas12f1 couples out-of-protospacer DNA unwinding with exonuclease activity in the sequential target cleavage. Nucleic acids res, 52, 14030-14042.
3. Zhao, Y., Guo, L., Hu, J., Ren, Z., Li, Y., Hu, M., Zhang, X., Bi, L., Li, D., Ma, H. et al. (2024) Phase-separated ParB enforces diverse DNA compaction modes and stabilizes the parS-centered partition complex. Nucleic acids res, 52, 8385-8398.
4. Wang, T., Hu, J., Li, Y., Bi, L., Guo, L., Jia, X., Zhang, X., Li, D., Hou, X.M., Modesti, M. et al. (2022) Bloom Syndrome Helicase Compresses Single-Stranded DNA into Phase-Separated Condensates. Angew Chem Int Ed Engl, 61, e202209463.
5. Bi, L., Qin, Z., Wang, T., Li, Y., Jia, X., Zhang, X., Hou, X.M., Modesti, M., Xi, X.G. and Sun, B. (2022) The convergence of head-on DNA unwinding forks induces helicase oligomerization and activity transition. Proc Natl Acad Sci U S A, 119, e2116462119.
科研活動(dòng)
1．2025年受邀參加第七屆全國核糖核酸（RNA）青年學(xué)術(shù)會(huì)議，并作專題報(bào)告
