◆個人概況
姓 名：王 磊 性 別： 男 出生年月：1983-11-26
學(xué) 位：博 士 職 稱： 副教授
研究方向：通過生物信息大數(shù)據(jù)挖掘和高通量組學(xué)技術(shù)來研究基因表達(dá)調(diào)控機制
通訊地址：河南省信陽市南湖路237號信陽師范學(xué)院生命科學(xué)學(xué)院413房間
聯(lián)系電話：0376-6391380; E_mail：wangleibio@gmail.com
◆教育背景
● 2002/09-2006/07，信陽師范學(xué)院，本科
● 2006/09-2009/06 信陽師范學(xué)院，碩士 （導(dǎo)師：袁紅雨 教授 & 劉彥明 教授）
● 2011/09-2014/06 復(fù)旦大學(xué)生命科學(xué)學(xué)院，博士（導(dǎo)師：馬 紅 教授）
◆工作經(jīng)歷
● 2009/09- 2011/06 復(fù)旦大學(xué)植物科學(xué)研究所， 科研助理
● 2014/07- 2016/12 信陽師范學(xué)院生命科學(xué)學(xué)院， 講師
● 2016/12- 2019/12 中科院生物物理研究所， 博士后 （合作導(dǎo)師：薛愿超 研究員）
● 2021/01-至今 信陽師范學(xué)院生命科學(xué)學(xué)院 副教授
◆研究方向
● 動植物基因家族的功能性進(jìn)化研究
● 利用生物信息學(xué)手段并結(jié)合多組學(xué)測序技術(shù)，深入開展RNA結(jié)合蛋白和非編碼RNA在人類疾病中的功能研究
● 利用先進(jìn)基因編輯技術(shù)CRISPR-Cas9和單細(xì)胞測序技術(shù)開展腫瘤異質(zhì)性和耐藥性研究
◆研究項目（主持和主要參加）
● 利用轉(zhuǎn)錄組學(xué)解析大豆親本和子代減數(shù)分裂細(xì)胞的差異（162300410257），河南省科技廳項目2016.1-2019.12，8萬元，主持
● Pri-miRNA加工機器的篩選及功能機制研究(31701109),國家自然科學(xué)基金青年項目，26萬元，主持
◆獲得獎勵
● 2016 信陽師范學(xué)院青年骨干教師
● 2017 信陽師范學(xué)院優(yōu)秀教師
● 2018 信陽師范學(xué)院優(yōu)秀碩士研究生指導(dǎo)教師
● 2018 河南省優(yōu)秀碩士研究生指導(dǎo)教師
● 2019 信陽師范學(xué)院首屆研究生十佳導(dǎo)師
◆發(fā)表文章(*Corresponding author, #Equal contributors)
1) Su R, Fan LH, Cao C, Wang L, Du Z, Cai Z, Ouyang YC, Wang Y, Zhou Q, Wu L, Zhang N, Zhu X, Lei WL, Zhao H, Tian Y, He S, Wong CCL, Sun QY, Xue Y. Global profiling of RNA-binding protein target sites by LACE-seq. Nature Cell Biology. 2021, 23(6):664-675. (SCI IF: 20.0)
2) Zhaokui Cai#, Changchang Cao#, Lei Ji#, Rong Ye, Di Wang, Cong Xia, Sui Wang, Zongchang Du, Naijing Hu, Xiaohua Yu, Juan Chen, Lei Wang, Xianguang Yang, Shunmin He & Yuanchao Xue*. (2020). Ric-seq for global in situ profiling of rna–rna spatial interactions. Nature, 1-6.(SCI IF: 43.0)
3) Lian, Shuaibin#*, Li, Liansheng#, Zhou, Yongjie, Liu, Zixiao, and Wang, Lei* (2019). The co-expression networks of differentially expressed RBPs with TFs and LncRNAs related to clinical TNM stages of cancers. PeerJ 7, e7696. .( SCI IF: 1.8)
4) Zhang, Pengpeng, Chao, Zhe, Zhang, Rui, Ding, Ruoqi, Wang, Yaling, Wu, Wei, Han, Qiu, Li, Cencen, Xu, Haixia, Wang, Lei* and Yongjie Xu* (2019). Circular RNA Regulation of Myogenesis. Cells 8, 885.( SCI IF: 5.7)
5) Wang, Lei#, Shi, Yan#, Chang, Xiaojun#, Jing, Shengli, Zhang, Qunjie, You, Chenjiang, Yuan, Hongyu*, and Wang, Haifeng* (2019). DNA methylome analysis provides evidence that the expansion of the tea genome is linked to TE bursts. Plant biotechnology journal 17, 826-835(SCI IF: 6.5)
6) Chen, Juan#, Cai, Zhaokui#, Bai, Meizhu#, Yu, Xiaohua#, Zhang, Chao#, Cao, Changchang, Hu, Xihao, Wang, Lei, Su, Ruibao, and Wang, Di (2018). The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes. Cell research 28, 981. (SCI IF: 17.848)
7) Zhang, Zaibao#, Ke, Danxia#, Hu, Menghui, Zhang, Chi, Deng, Lijun, Li, Yuting, Li, Jiuli, Zhao, Hai, Cheng, Lin, and Wang, Lei* and Hongyu Yuan* (2019). Quantitative phosphoproteomic analyses provide evidence for extensive phosphorylation of regulatory proteins in the rhizobia–legume symbiosis. Plant molecular biology 100, 265-283.( SCI IF: 2.9)
8) Han, Yapeng, Li, Xiangyong, Cheng, Lin, Liu, Yanchun, Wang, Hui, Ke, Danxia, Yuan, Hongyu, Zhang, Liangsheng, and Wang, Lei* (2016). Genome-wide analysis of soybean JmjC domain-containing proteins suggests evolutionary conservation following whole-genome duplication. Frontiers in plant science 7, 1800. ( SCI IF: 4.4)
9) Ke, Danxia*, Li, Xiangyong, Han, Yapeng, Cheng, Lin, Yuan, Hongyu, and Wang, Lei* (2016). ROP6 is involved in root hair deformation induced by Nod factors in Lotus japonicus. Plant Physiology and Biochemistry 108, 488-498. ( SCI IF: 2.7)
10) Xiaolong Fang#, Lei Wang#, Xiaojuan Deng, Peng Wang, Qibin Ma, Hai Nian, Yingxiang Wang*, Cunyi Yang*. Genome-wide characterization of soybean P1B-ATPases gene family provides functional implications in cadmium responses.BMC Genomics,2016, 17, 376. (SCI IF: 3.8)
11) Cheng Lin, Hong-Yu Yuan, Ren Ren, Shi-Qi Zhao, Ya-peng Han, Qi-Ying Zhou, Dan-Xia Ke, Ying-xiang Wang*, Wang Lei*. Genome-wide identification, classification and expression analysis of amino acid transporter gene family in Glycine max. Frontiers in Plant Science, 2016, 7: 00515. (SCI IF: 4.4)
12) Hongxing Yang?, Fang Chang*,?, Chenjiang You, Jie Cui, Genfeng Zhu, Lei Wang, Yu Zheng, Ji Qi*, Hong Ma*. Whole-genome DNA methylation patterns and complex associations with gene structure and expression during flower development in Arabidopsis. Plant Journal, 2015，81: 268–281. (SCI IF: 6.5)
13) Liangsheng Zhang, Lei Wang, Yulin Yang, Jie Cui, Fang Chang, Yingxiang Wang3*, Hong Ma*. Analysis of Arabidopsis floral transcriptome: detection of new florally expressed genes and expansion of Brassicaceae-specific gene families. Frontiers in Plant Science, 2015, 5:00802. (SCI IF: 4.4)
14) Lei Wang?, Chenlong Cao?, Qibin Ma, Qiaoying Zeng, Haifeng Wang, Zhihao Cheng, Genfeng Zhu, Ji Qi, Hong Ma, Hai Nian*, Yingxiang Wang*. RNA-seq analyses of multiple meristems of soybean: novel and alternative transcripts, evolutionary and functional implications. BMC Plant Biology, 2014, 14:169. (SCI IF: 4.7)
15) Haifeng Wang1,2?, Chenjiang You?, Fang Chang, Yingxiang Wang, Lei Wang, Ji Qi*, Hong Ma*. Alternative splicing during Arabidopsis flower development results in constitutive and stage-regulated isoforms. Frontiers in Genetics, 2014, 5:00025. (SCI IF: 3.5)
16) Hongxing Yang, Yan Zhou, Jianlei Gu, Shuying Xie, Yao Xu, Genfeng Zhu, Lei Wang, Jiyue Huang, Hong Ma*, Jihua Yao*. Deep mRNA Sequencing Analysis to Capture the Transcriptome Landscape of Zebrafish Embryos and Larvae. PLoS ONE, 2013, 8(5), e64058. (SCI IF: 3.0)
17) Huimin Yang, Suxia Xie, Lei Wang, Shengli Jing, Xiaopei Zhu, Xianwen Li, Wei Zeng, Hongyu Yuan*, Identification of up-regulated genes in tea leaves under mild infestation of green leafhopper, Scientia Horticulturae, 2011, 130(2): 476-481. (SCI IF: 1.5)
18) Lei Wang, Xianwen Li, Qin Zhao, Shengli Jing, Shifeng Chen, Hongyu Yuan*. Identification of Genes Induced in Response to Low-Temperature Treatment in Tea Leaves. Plant Molecular Biology Reporter, 2009, 27(3): 257-265. (SCI IF: 2.3)
◆ 參加會議
1）第十七屆全國植物基因組學(xué)大會（Plant Genomic in China），2016年8月19－22日，中國 福州
2）2016全國植物生物學(xué)大會(National Congress of Plant Biology)， 2016年10月9日－12日，中國 武漢
3）2016世界生命科學(xué)大會 (WORLD LIFE SCIENCE CONFERENCE,WLSC2016)，2016年11月1日-3日，中國 北京
4）顛覆性技術(shù)國際研討會（International workshop on Disruptive Technologies—Disruptive Technologies in Biology and Crossing Fields），2016年11月23日-25日，中國 北京
5）河南省遺傳學(xué)會2018年學(xué)術(shù)年會大會報告，河南 駐馬店
6）2019 Keystone Symposia in Daejeon (Small Regulatory RNAs) 大會報告，韓國 大田
