個(gè)人概況
徐永杰，男，河南商城人。博士，教授，碩士生導(dǎo)師，河南省青年骨干教師，河南省教育廳學(xué)術(shù)技術(shù)帶頭人，河南省大別山農(nóng)業(yè)生物資源保護(hù)工程技術(shù)研究中心主任，主要從事動(dòng)物分子遺傳等方面的教學(xué)科研工作。教學(xué)方面，主講本科生《生物化學(xué)》、《生物技術(shù)大實(shí)驗(yàn)》以及研究生《高級(jí)生物化學(xué)》、《表觀遺傳學(xué)》等課程；科研方面，主要研究領(lǐng)域和方向包括動(dòng)物肌肉發(fā)育與脂肪沉積的分子調(diào)控機(jī)制、動(dòng)物雄性生殖調(diào)控、動(dòng)物功能基因組學(xué)等，圍繞這些領(lǐng)域主持承擔(dān)了國(guó)家自然科學(xué)基金、河南省自然科學(xué)基金、河南省科技攻關(guān)、河南省高層次人才國(guó)際化培養(yǎng)項(xiàng)目等10余項(xiàng)。國(guó)家自然科學(xué)基金委通訊評(píng)審專(zhuān)家，浙江省科技項(xiàng)目評(píng)審專(zhuān)家，教育部學(xué)位中心學(xué)位論文通訊評(píng)議專(zhuān)家，河南省遺傳學(xué)會(huì)理事；Frontiers in Cell and Developmental Biology雜志review editor， FASEB J、JAS、JCP、Gene、遺傳、農(nóng)業(yè)生物技術(shù)學(xué)報(bào)等國(guó)內(nèi)外雜志審稿人。以第一或通訊作者在Frontiers in Cell and Developmental Biology、Open biology、Genomics、Cells、Journal of Proteomics、BMB Reports、畜牧獸醫(yī)學(xué)報(bào)等國(guó)內(nèi)外重要學(xué)術(shù)期刊發(fā)表學(xué)術(shù)論文40余篇；以副主編在科學(xué)技術(shù)出版社出版專(zhuān)著1部，授權(quán)國(guó)家發(fā)明專(zhuān)利1項(xiàng)；獲第四屆中國(guó)畜牧科技優(yōu)秀論文獎(jiǎng)和河南省自然科學(xué)優(yōu)秀學(xué)術(shù)論文一等獎(jiǎng)各1項(xiàng)，榮獲信陽(yáng)市第十屆青年科技獎(jiǎng)，入選河南省高層次人才C類(lèi)，被評(píng)為信陽(yáng)師范學(xué)院第二屆“十佳導(dǎo)師”；指導(dǎo)碩士研究生8人，其中3人獲得研究生國(guó)家獎(jiǎng)學(xué)金，5人畢業(yè)論文被評(píng)為信陽(yáng)師范學(xué)院優(yōu)秀碩士論文，1人畢業(yè)論文被評(píng)為河南省優(yōu)秀碩士學(xué)位論文。
教育經(jīng)歷
2005.9-2010.6 華中農(nóng)業(yè)大學(xué) 動(dòng)物遺傳育種與繁殖 博士
2001.9-2005.6 河南農(nóng)業(yè)大學(xué) 動(dòng)物科學(xué) 學(xué)士
工作經(jīng)歷
2021.12-至今 信陽(yáng)師范學(xué)院生命科學(xué)學(xué)院 教授
2019.02-2020.07 夏威夷大學(xué)馬諾分校 訪(fǎng)問(wèn)學(xué)者
2015.04-2016.05 夏威夷大學(xué)馬諾分校 訪(fǎng)問(wèn)學(xué)者
2014.11-2021.11 信陽(yáng)師范學(xué)院生命科學(xué)學(xué)院 副教授
2010.07- 2014.10 信陽(yáng)師范學(xué)院生命科學(xué)學(xué)院 講師
研究領(lǐng)域
1．動(dòng)物肌肉發(fā)育與脂肪沉積的分子調(diào)控機(jī)制
2．動(dòng)物雄性生殖調(diào)控
主持科研項(xiàng)目
1. 國(guó)家自然科學(xué)基金面上項(xiàng)目，RNA 結(jié)合蛋白hnRNPK與miRNAs 互作調(diào)控豬骨骼肌衛(wèi)星細(xì)胞分化與骨發(fā)育的分子機(jī)理 (31972537），2020.1.1-2023.12.31, 57.0萬(wàn)元，在研。
2. 河南省科技攻關(guān)項(xiàng)目，hnRNPK-miR125b互作介導(dǎo)的IGF2信號(hào)通路在豬骨骼肌發(fā)育中的調(diào)控機(jī)制及應(yīng)用（222102110013），2022.1.1-2023.12.31, 10.0萬(wàn)元，在研。
3. NSFC-河南省聯(lián)合基金，Hnrnpk 基因在豬成肌細(xì)胞增殖分化過(guò)程中的表達(dá)及分子調(diào)控機(jī)制研究（U1204326），2013.1.1-2015.12.31，30.0萬(wàn)元，結(jié)項(xiàng)。
4. 河南省自然科學(xué)基金面上項(xiàng)目，豬骨骼肌成肌細(xì)胞增殖與分化過(guò)程中Hnrnpk與c-Src相互作用的分子機(jī)制（182300410027），2018.1.1-2019.12.31，10.0萬(wàn)元，結(jié)項(xiàng)。
5. 河南省科技攻關(guān)，骨骼肌成肌分化過(guò)程中關(guān)鍵circRNA的篩選鑒定及功能分析（182102310211），2018.1.1-2019.12.31，結(jié)項(xiàng)。
6. 河南省“三區(qū)”人才支持計(jì)劃科技人員專(zhuān)項(xiàng)，地方黑豬的養(yǎng)殖與管理技術(shù)，2018.6-2020.6，6萬(wàn)元。
7. 河南省青年骨干教師資助計(jì)劃項(xiàng)目，豬骨骼肌成肌細(xì)胞分化過(guò)程中c-src基因的表達(dá)調(diào)控機(jī)制研究（2015GGJS-139），2016.1.1-2018.12.31，2萬(wàn)元，結(jié)項(xiàng)。
發(fā)表高層次論文
1. Xu Haixia#, Jiahua Guo#, Wei Wu#, Qiu Han, Yueru Huang, Yaling Wang, Cencen Li, Xiaofang Cheng, Pengpeng Zhang*, and Yongjie Xu*. Deletion of Hnrnpk Gene Causes Infertility in Male Mice by Disrupting Spermatogenesis. Cells, 2022, 8: 1277.
2. Xu Haixia, Han Qiu, Wang Yaling, Chen Ning, Cheng Xxiaofang, Yu Shulong, Li Cencen, Zhang Pengpeng, Xu Yongjie*. Effect on Gene Expression Profile of hnRNPK Knockdown in Mouse GC-1spg Cells. J. Anim. Plant Sci., 2022, 32: 538-546.
3. Zhang Pengpeng, Wu Wei, Du Chunyu, Ji Xiang, Wang Yaling, Han Qiu, Haixia Xu, Cencen Li*, Yongjie Xu*. RNA-seq profiling of white and brown adipocyte differentiation treated with epigallocatechin gallate. Sci Data, 2022, 9(1): 41.
4. Zhang Pengpeng, Wu Wenyan, Ma Chaofeng, Du Chunyu, Huang Yueyu, Xu Haixia, Li Cencen, Cheng Xiaofang, Hao Ruijie, Xu Yongjie*. RNA-Binding Proteins in the Regulation of Adipogenesis and Adipose Function. Cells, 2022, 11(15): 2357.
5. Zhang Pengpeng, Sheng Mingxuan, Du Chunyu, Chao Zhe, Xu Haixia, Cheng Xxiaofang, Cencen Li*, Yongjie Xu*. Assessment of CircRNA Expression Profiles and Potential Functions in Brown Adipogenesis. Front Genet, 2021, 12: 769690.
6. Yongjie Xu#, Qiu Han#, Chaofeng Ma#, Yaling Wang, Pengpeng Zhang, Cencen Li, Xiaofang Cheng, Haixia Xu*. Comparative Proteomics and Phosphoproteomics Analysis Reveal the Possible Breed Difference in Yorkshire and Duroc Boar Spermatozoa. Frontiers in Cell and Developmental Biology, 2021, 9: p. 652809.
7. Pengpeng Zhang, Qiu Han, Mingxuan Sheng, Chunyu Du, Yaling Wang, Xiaofang Cheng, Haixia Xu, Cencen Li*, Yongjie Xu*. Identification of Circular RNA Expression Profiles in White Adipocytes and Their Roles in Adipogenesis. Frontiers in Physiology, 2021, 12: p.728208.
8. Yongjie Xu, Haixia Xu, Marisa M. Wall, Jinzeng Yang*. Roles of transcription factor SQUAMOSA promoter binding protein-like gene family in papaya (Carica papaya) development and ripening. Genomics, 2020, 112(4): 2734-2747.
9. Li Cencen, Yu Shulong, Ren Haifeng, Wu Wei, Wang Yaling, Han Qiu, Xu Haixia, Xu Yongjie*, Zhang Pengpeng*. Identification and functional prediction of long intergenic noncoding RNAs in fetal porcine longissimus dorsi muscle. Journal of Integrative Agriculture, 2021, 19(1): 2-12.
10. Ning Kong, Qiong Meng, Yajuan Jiao, Yongguang Wu, Yewen Zuo, Hua Wang, Dage Sun, Sujie Dong, Huanjie Zhai, Wu Tong, Hao Zheng, Hai Yu, Guangzhi Tong, Yongjie Xu* and Tongling Shan*. Identification of a novel B-cell epitope in the spike protein of porcine epidemic diarrhea virus. Virology Journal, 2020, 17(1): 46.
11. Pengpeng Zhang, Zhe Chao, Rui Zhang, Ruoqi Ding, Yaling Wang, Wei Wu, Qiu Han, Cencen Li, Haixia Xu, Lei Wang, and Yongjie Xu*. Circular RNA Regulation of Myogenesis. Cells, 2019, 8: 885.
12. Yongjie Xu, Wei Wu, Qiu Han, Yaling Wang, Cencen Li, Pengpeng Zhang*, Haixia Xu*. Post-translational modification control of RNA-binding protein hnRNPK function. Open Biology, 2019, 9(3): 190239.
13. Yongjie Xu, Wei Wu, Qiu Han, Yaling Wang, Cencen Li, Pengpeng Zhang*, Haixia Xu*. New Insights into the Interplay between Non-Coding RNAs and RNA-Binding Protein HnRNPK in Regulating Cellular Functions. Cells, 2019, 8(1): 62.
14. Yongjie Xu, Rui Li, Kaili Zhang, Wei Wu, Pengpeng Zhang*, Haixia Xu*. The multifunctional RNA-binding protein hnRNPK is critical for the proliferation and differentiation of myoblasts. BMB Reports, 2018, 51(7): 350-355.
15. Pengpeng Zhang#, Haixia Xua#, Rui Li#, Wei Wu, Zhe Chao, Cencen Li, Wei Xia, Lei Wang, Jinzeng Yang, Yongjie Xu*. Assessment of myoblast circular RNA dynamics and its correlation with miRNA during myogenic differentiation. International Journal of Biochemistry and Cell Biology, 2018, 99: 211-218.
16. Haixia Xu, Yongjie Xu*, Xiaojuan Liang,Yanbo Wang, Fangfang Jin, Dengying Liu, Yun Ma , Hongyu Yuan, Xinqiang Song, Wenxian Zeng*. Porcine skeletal muscle differentially expressed gene ATP5B: molecular characterization, expression patterns and association analysis with meat quality traits. Mammalian Genome, 2013, 24(3-4): 142-150.
17. Xu Yongjie, Qian Hui, Feng Xiaoting, Xiong Yuanzhu*, Lei Minggang Ren Zhuqing, Zuo Bo, Xu Dequan, Ma Yun, Yuan Hongyu. Differential proteome and transcriptome analysis of porcine skeletal muscle during development. Journal of Proteomics, 2012, 75(7): 2093-2108.
18. Xu Yongjie, Yu Wenmin, Feng Xiaoting, Xie Hongtao, Xiong Yuanzhu*. Molecular Characterization, Expression Patterns, and Polymorphism of a Differentially Expressed Porcine Gene (PYGM) Isolated by Suppression Subtractive Hybridization and Two-Dimensional Gel Electrophoresis Analysis. DNA and Cell Biology, 2012, 31(1): 98-105.
19. Xu Yongjie, Jin Meilin, Wang Linjie, Zhang Anding, Zuo Bo, Xu Dequan, Ren Zhuqing, Lei Minggang, Mo Xiaoyu, Li Fenge, Zheng Rong, Deng Changyan, Xiong Yuanzhu. Differential proteome analysis of porcine skeletal muscles between Meishan and Large White. Journal of Animal Science, 2009, 87: 2519-27.
20. Xu Yongjie, Yu Wenmin, Xiong Yuanzhu*, Xie Hongtaio, Ren Zhuqing, Xu Dequan, Lei Minggang, Zuo Bo, Feng Xiaoting. Molecular characterization and expression patterns of serine/arginine-rich specific kinase 3 (SPRK3) in porcine skeletal muscle. Molecular Biology Report, 2011, 38(5): 2903-9.
聯(lián)系方式：
辦公室：敏思樓520；郵箱：xyj@xynu.edu.cn; yongjx81@126.com
